Journal of Biomedical and Engineering Research
ISSN: 3065-8780 | DOI: 10.64030/3065-8780
Angela Nnenna Ukwuani-Kwaja, Abdulhamid Zubairu, Binta Saidu, Yusuf Sani, Jibril Muhammed, Umar Usman Maidahini, Ibrahim Zakariya Lafiya and Kabiru Salihu
Sexual dysfunction in male (hypogonadism erectile and ejaculatory disorders,) is a significant global public health issue, affecting over 20% of males. While synthetic therapies exist, their adverse effects drive interest in plant-based alternatives. Securidaca longipedunculata is traditionally used for enhancing sexual function, but scientific validation is limited. This study evaluated the aphrodisiac efficacy of S. longipedunculata stembark methanol extract on male albino rats. Phytochemical screening using standard protocols revealed tannins, flavonoids, steroids, and alkaloids. Fifteen rats were divided into five groups (n=3): Group 1 (control, distilled water 5mL/kg), Group 2 (standard, sildenafil citrate 5 mg/kg), and Groups 3–5 (received extract at 100, 200, 400mg/kg b. wt respectively). Extract and sildenafil citrate were ingested daily for 14 days. Mating behaviors: Post-ejaculation interval (PEI), ejaculation latency (EL), mount frequency (MF), intromission frequency (IF), mount latency (ML), and intromission latency (IL), were recorded at baseline (week 0), week 1, and week 2. Posttreatment
mating performance was also assessed. Baseline parameters showed no significant differences (P > 0.05). Posttreatment, extract- and sildenafil-treated groups exhibited significant (P < 0.05) reductions in PEI IL, and ML, compared with controls. EL increased significantly (P < 0.05) in all treated groups, while IF showed non-significant elevation (P > 0.05). Dose-dependent improvements in mating performance were observed in extract groups. S. longipedunculata stembark methanol extract demonstrated significant aphrodisiac activity, likely mediated by its bioactive constituents. These findings validate its traditional use as a sexual enhancer and warrant further investigation into its mechanisms of action.