Cardiology & Vascular Research

Assessment of Medication Adherence and Factors Among Hypertensive Patients

Abstract

Mujahid Ali, Ali Akhtar, Waqas Akram, Mahtab Ahmad Khan, Muhammad Nadeem Alvi, Muhammad Abbas Raza, Israr Tanveer, Muhammad Hammad, Muhammad Sabtain Abbas, Hassan Ahmad and Mirza Usama

Objective: To determine factors related to the prevalence of drug compliance and insufficient adherence to lowering blood pressure treatment. Investigating patient-related factors and health systems associated with reduced compliance with blood pressure-lowering medications.

Method: This quantitative cross-section study was conducted in Johar Town, Lahore, from 17 to 31 March 2025 and is targeted at adult hypertensive patients. A sample of 350 18-year-old patients with hypertension diagnosed for more than 1 year took part in blood pressure-lowering medications and outpatient follow-up tests. Information was collected on health system factors and care driver factors for violations with patients with self-reported and revised scales to comply with Hill's bone.

Result: Of the 350 participants, 173 (49.4%) were males and 176 (50.6%) were females. Participants' income was categorized into 87 low-income class, 189 middle-income class, and 73 high-income class. The most frequent comorbidities included diabetes (72 patients) and heart failure (79 patients). Based on self-reports, 174 (49.7%) patients were unsuitable for blood pressurelowering medications. Patients who were affected by noncompliance included the number of drugs collected, side effects, and missed appointments. Patients who received three blood pressure-lowering medications were less likely to adhere compared to drug therapy (OR 0.8; 95% CI 0.3°C). The incidence of diarrhea as a side effect also reduced the lack of compliance (OR 0.9; 95% CI 0.5°C) and clinical appointments due to lack of change in compliance (OR 0.5; 95% CI 0.2°C). According to the modified Hill bone suitability scale, patients who could name the drug were quite glued (OR 1.4; 95% CI 0.8°2.5). Health system-related factors also played a role. Self-reports noted that lack of booking significantly reduced compliance (OR 0.4; 95% CI 0.2 4.7). A moderate correlation was found between self-reported compliance and modified Columbine scales.

Conclusion: The prevalence of compliance among hypertensive patients was 50.3%. Side effects of dizziness and cancellations due to unavailability of transport were factors related to non-attendance. Compliance with BP drugs and counseling on medication intake were both related to decreased noncompliance

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