Journal of Cancer Research
ISSN: 2578-3726 | DOI: 10.64030/2578-3726
Rebecca Golin and Hengrui Liu
Asymmetric cell division (ACD) plays a crucial role in normal cellular differentiation and tissue homeostasis. The mechanisms
of ACD are highly intricate, involving coordinated molecular and cellular processes. Dysregulation of ACD has been implicated
in various human cancers, contributing to malignant tumor initiation, progression, metastasis, and resistance to treatment.
Although numerous studies have explored the relationship between ACD and cancer, many questions remain unanswered. This
literature review aims to evaluate the potential biological significance of ACD in cancer, with a particular focus on its diagnostic
and prognostic relevance. A comprehensive PubMed search was conducted from 2008 to the present, using keywords such as
"asymmetric cell division," "cancer," "glioblastoma," and "tumorigenesis." The selected articles were analyzed to assess ACD-
related data and their clinical correlations. Special emphasis was placed on glioblastoma, an aggressive brain tumor with limited
advancements in patient survival over recent years. The review underscores the crucial role of ACD in normal tissue homeostasis
and its dysregulation in cancer initiation, progression, therapeutic resistance, and metastatic potential. Understanding how
ACD contributes to cancer heterogeneity may provide insights into innovative strategies for tumor detection, monitoring, and
treatment. Future research into the molecular mechanisms governing ACD could facilitate the development of novel cancer
therapies aimed at restoring or modulating ACD processes to improve patient outcomes.