CME Journal of Medical Microbiology
ISSN: 3070-3638 | DOI: 10.64030/3070-3638
Vasanthabharathi Venkataraman and Kalaiselvi Vaithi
Annually, lower respiratory tract infections (LRTIs) cause about 2.3 million mortality and 6.6 million morbidity in children under the age of five around the globe [1]. Globally, these infections are common in children below five and are growing, especially in deprived regions [2]. A number of microbes cause LRTTS, which includes bacteria, fungi, and respiratory tract infectious viruses. Globally, major viral pathogens, including influenza virus coronavirus, adenovirus, and rhinovirus cause severity in children. However, the pandemic notably diminished the prevalence of non-COVID-19 respiratory viruses, with a 90% decrease in victims excluding adenovirus and enterovirus were recorded [3]. The respiratory epithelium contains a diversified associated microbiota but respiratory microbial research and findings were very less because of the complicated unculturable microbiome of the respiratory system. [4,5]. Significant progress is being made in developing host responsebased diagnostics for Acute respiratory infections(ARI). One of the major developments is protein biomarkers and «omics» methods including proteomics, metabolomics, and transcriptomics technology [1,6]. Global and National programs against lower respiratory infections and other common diseases, such as Every Breath Counts, the Global Action Plan for Pneumonia and Diarrhoea (GAPPD), and the Stop Pneumonia Initiative, are being implemented [7]. This review provides an overview of the global, regional, and national impact of LRIs and explores the role of microbial origins in LRTIs.