Bhanumati Dutta, Pares Bandyopadhyay and Uma Adhikari
Introduction: Adherence to secondary prevention medication after Myocardial revascularisation is imperative in slowing the progression of atherosclerosis in both native and grafted vessels [1,2]. Patients who experience impaired quality of life (QOL) have reported low medication adherence. [3] Health care professionals such as physicians, pharmacists and nurses have significant role in their daily practice to improve patient medication adherence [ 4].
Objectives: The objectives of the study were to assess the level of adherence to drug regimen, to explore potential factors of adherence to drug regimen and to assess quality of life among patients who have undergone myocardial revascularization.
Methodology: A quantitative research approach and prospective longitudinal cohort study design was adopted to collect data from forty (40) patients who have undergone either PTCA or CABG, selected by nonprobability convenience sampling technique. ARMS, SF-36 short form and an interview schedule were used to collect data from the subject within one month and at three months after revascularisation.
Result: The study result shows that majority (82.5%) of the patients with myocardial revascularization were adherent to drug regimen at initial month after revascularization but reduced to 55% after three months(p<0.05). The percentage of adherence with medication was reduced from 80% to 55 % after 3 months among patients with CABG whereas percentage of adherence among patient with PTCA was also reduced from 85% to 55% after 3 months((p<0.05). The associated factor was history of smoking but not established as a predictive factor for adherence to drug regimen. The quality of life separated in two main domains of Physical component summary and Mental component summary of patient with myocardial revascularisation were improved from one month to 3 months after intervention (p<0.001). Physical component summary (PCS) and Mental component summary (MCS) of Quality of life had no significant relationship with adherence to drug regimen at 3 months’ time period.
Conclusion: Adherence to drug regimen was decreased over time but Quality of life was improved among patients with myocardial revascularisation. There was no significant relationship found between adherence to drug regimen with PCS and MCS domain of quality of life among patients with myocardial revascularisation. Pilot study result showed feasibility and practicability to conduct main study without further modification of research design.